The Science

Burak Multiomics is a deterministic, explainable bio-computational engine designed to detect sub-clinical metabolic drift before it manifests as late-stage disease. The platform converts heterogeneous lab and microbiome inputs into standardized, auditable signals, then computes risk using time-series logic and a rules-based cohort mapping system.

The scientific logic is grounded in Burak’s internal Sovereign Source of Truth specification (v2.0.0, March 25, 2026), which defines ingestion hygiene, units, privacy constraints, marker thresholds, and cohort routing rules.

Before any scoring, incoming reports pass a strict ingestion and hygiene gate designed to preserve true pathology while rejecting impossible values.

Unit normalization

Laboratory values are normalized into master units before computation, including glucose and lipids in mg/dL, hs-CRP in mg/L, creatinine in mg/dL, HbA1c in percent, insulin in μIU/mL, zonulin in ng/mL, and microbiome taxa in percent relative abundance.

Limits of life

Extreme-but-possible values are preserved and flagged. Values outside biological possibility are rejected as pre-analytical error. Examples of keep-and-flag ranges include glucose up to 1,500 mg/dL, ALT/AST up to 10,000 U/L, triglycerides up to 5,000 mg/dL, hs-CRP up to 350 mg/L, and ferritin up to 15,000 ng/mL.

Privacy

No names, emails, or phone numbers are allowed in science processing. Longitudinal linkage uses a SHA-256 hash identifier derived from a national ID and a salt.

Acute management

An acute management gate runs before cohort routing and velocity math. Triggers include WBC above 11.0 with neutrophils above 70 percent, or CRP above 10.0 mg/L, each with a sudden delta from baseline. Those values are quarantined from chronic cohorts.

Phase 1 accepts markers across metabolic, inflammation, gut integrity, renal and liver, cardiovascular, thyroid, nutrient, and microbiome domains. Examples of critical thresholds include glucose above 126 mg/dL, HbA1c above 6.5 percent, insulin above 25 μIU/mL, triglycerides above 200 mg/dL, and hs-CRP above 3.0 mg/L.

Derived fields include HOMA-IR, the triglyceride/HDL ratio, the Firmicutes/Bacteroidetes ratio, BMI, CKD-EPI 2021 eGFR, and VAI.

If no red markers exist but there are at least four yellow markers across categories, the profile routes to an early-warning pathway rather than a healthy classification. Shared markers such as CRP and zonulin follow a primary and secondary hierarchy so risk is not double counted.