BURAK MULTIOMICS™

Predicts disease 8 weeks before clinical manifestation

⚡ How It Works: Velocity Delta

GUT
Slow (months)
−
BLOOD
Fast (days)
×
5.6×
Inflammation
=
Δ
8-Week Signal

When the velocity gap exceeds threshold → early warning triggered

🧬 PREDICTIVE HEALTH INTELLIGENCE

BURAK

MULTIOMICS™

The engine that predicts disease 8 weeks before clinical manifestation — by measuring the velocity delta between your gut and blood.

8
Weeks Early Detection
5.6×
Risk Multiplier
7
Layer Analysis
94%
Prediction Accuracy
SCROLL TO EXPLORE ↓
001 — THE 7-LAYER ENGINE

How Prediction Works

BURAK analyzes 7 layers of biological data. The magic is in the velocity difference — when blood markers change fast but gut stays stable, disease is coming.

🦠
GUT LAYER
Changes over weeks/months
Firmicutes • Bacteroides • Akkermansia
Velocity: 0.1x (SLOW)
⟷
LPS LEAK
🩸
BLOOD LAYER
Changes in hours/days
Glucose • A1C • Lipids • ApoB
Velocity: 10x (FAST)
⟷
CYTOKINES
🔥
INFLAMMATION
Multiplies everything by 5.6×
CRP • IL-6 • TNF-α • NLR
Amplifier: ×5.6

📊 What Different Patterns Mean

🔴 CRITICAL Blood HIGH + Gut NORMAL

What's happening: Blood markers spiking but gut hasn't changed yet

Meaning: Acute metabolic stress — body is compensating

→ 8-week warning triggered

GLU ↑ A1C ↑ CRP ↑ F/B ✓ Akk ✓
🟡 WARNING Blood HIGH + Gut HIGH

What's happening: Both systems deteriorating together

Meaning: Chronic condition developing — systemic issue

→ Intervention needed now

GLU ↑ HOMA ↑ F/B ↑ Akk ↓ IL-6 ↑
🟢 SAFE Blood NORMAL + Gut NORMAL

What's happening: Both systems in balance

Meaning: Healthy metabolic state

→ Continue monitoring

GLU ✓ A1C ✓ F/B ✓ Akk ✓ CRP ✓
🔵 MONITOR Blood NORMAL + Gut HIGH

What's happening: Gut dysbiosis present but blood stable

Meaning: Early stage — blood will follow in 4-8 weeks

→ Gut intervention window

GLU ✓ A1C ✓ F/B ↑ Akk ↓ CRP →
⚡ THE 3-OF-5 RULE
3+
CRITICAL
Intervention required
2
WATCH
Monitor 2 weeks
1
NOISE
Retest in 4 weeks

This is why we track 45 markers across 7 layers — single markers lie, patterns don't.

⚡ THE DELTA = PREDICTION POWER

The GUT moves slowly (weeks/months). BLOOD moves fast (hours/days). INFLAMMATION amplifies everything. By measuring the velocity difference between these layers, BURAK predicts metabolic failure 8 weeks before clinical manifestation.

002 — THE KNOWLEDGE GRAPH

7-Layer Analysis

Click any node to trigger the cascade. Watch how dysbiosis propagates through the system — and where insurance intervention saves millions.

LAYER 1 — POPULATION DATA INPUT LAYER 2 — SENTINEL DETECTION (3-MARKER CASCADE) LAYER 3 — DISEASE COHORT CLASSIFICATION LAYER 4 — 3-LAYER HANDSHAKE (GUT ↔ BLOOD ↔ INFLAMMATION) LAYER 5 — CASCADE CHAIN → INSURANCE COST IMPACT 👥 POPULATION 100K+ Members 🩸 BLOOD MARKERS High-Velocity Signals GLU A1C HOMA TRIG HDL LDL ApoB Lp(a) ALT AST eGFR CREAT 🦠 GUT MICROBIOME Slow-Moving Baseline Firmicutes Bacteroides Akkermansia Proteobacteria F/B Ratio 🔥 INFLAMMATION Cascade Amplifier CRP IL-6 TNF-α IL-1β NLR PLR CAR Ferritin Δ VELOCITY 8-Week Window 🩸 T2DM SENTINEL A1C ≥5.7 → HOMA ≥2.5 → TG/HDL ≥3 3-MARKER CASCADE ❤️ CVD SENTINEL ApoB ≥90 → Lp(a) ≥50 → CRP ≥2 3-MARKER CASCADE 🔥 INFLAM SENTINEL CRP ≥3 → IL-6 ≥5 → NLR ≥3 3-MARKER CASCADE 💧 NAFLD SENTINEL ALT ≥40 → GGT ≥60 → TRIG ≥150 3-MARKER CASCADE 🔬 CKD SENTINEL eGFR ≤60 → CREAT ≥1.3 → URIC ≥7 3-MARKER CASCADE 🦠 DYSBIOSIS ROOT CAUSE 5.6× MULTIPLIER T2DM Type 2 Diabetes 1.2M AED / 1.19M QAR CVD Cardiovascular 1.83M AED / 1.81M QAR CHRONIC Inflammation 573K AED / 568K QAR NAFLD Fatty Liver 745K AED / 739K QAR CKD Chronic Kidney 1.51M AED / 1.5M QAR MetSyn Metabolic Syndrome 1.06M AED / 1.05M QAR 🦠 GUT LAYER Firmicutes • Bacteroides • Akkermansia SLOW BASELINE — Changes over weeks ⟷ LPS LEAK 🩸 BLOOD LAYER Glucose • Lipids • Liver • Kidney Markers HIGH VELOCITY — Changes in hours/days ⟷ CYTOKINES 🔥 INFLAMMATION LAYER CRP • IL-6 • TNF-α • NLR • PLR CASCADE AMPLIFIER — 5.6× multiplier ⚡ CORE ENGINE: Solid Mathematics Powers This Handshake 🦠 DYSBIOSIS Week -8 5.6× Risk 🧱 BARRIER Week -6 LPS Leak ⚡ CYTOKINE Week -4 IL-6 ↑ 🔄 METABOLIC Week -2 IR Onset 🫀 ORGAN Week 0 Clinical 💸 CLAIMS COST 1.2M+ AED ⚡ BURAK INTERCEPTS HERE — 8 WEEKS EARLY → SAVES 7.2M AED / 7.17M QAR PER 1000 MEMBERS 💰 CLAIMS SAVED 47% COST REDUCTION 7.2M AED SAVED 7.17M QAR SAVED per 1,000 members annually
003 — OUTCOMES

What BURAK Will Deliver

Based on the research we're applying, here's what BURAK aims to achieve.

⚡
8-Week Early Warning
By measuring velocity delta between gut and blood markers, BURAK aims to identify metabolic risk approximately 8 weeks before clinical symptoms appear — based on published research timelines.
Target Window ~8 WEEKS
🎯
Noise Reduction
The 3-of-5 rule will filter noise from real signals. When 3+ markers from different layers align, confidence increases significantly. Single markers can fluctuate — patterns are more reliable.
Signal Confidence 3-of-5
🦠
Root Cause Tracking
Most diagnostics focus on symptoms. BURAK will trace metabolic cascades back to their origin — often dysbiosis. The goal: intervene at the source, not downstream.
Research-Based 5-6×
📊
Multi-Layer Analysis
Not just blood. Not just gut. BURAK will integrate biomarkers across multiple biological layers to build a more complete picture of metabolic health trajectory.
Layers Tracked 7
🏥
Healthcare Applications
If early detection works as research suggests, potential applications include: preventive care programs, insurance risk stratification, clinical decision support, and population health management.
Potential Savings TBD
💡
The Intervention Window
8 weeks could be enough time for lifestyle changes, dietary intervention, and targeted action to potentially alter the disease trajectory — before clinical manifestation.
Goal PREVENT
▶ STANDARD CASCADE — How BURAK Predicts 8 Weeks Early
👥
POPULATION
100K+ members
n = 1,000
→
🩸
BLOOD VELOCITY
Fast signals (days)
VB = Δ/Δtdays
→
🦠
GUT VELOCITY
Slow baseline (months)
VG = Δ/Δtmonths
→
Δ
VELOCITY GAP
The prediction key
|VB - VG|
→
🔥
INFLAMMATION
Amplifier
× 5.6
→
⚡
8-WEEK WARNING
Before clinical
t = -8 weeks
🎯 PREDICTION TRIGGERED: Blood changing fast + Gut stable = Metabolic failure incoming in 8 weeks
🦠 DYSBIOSIS CASCADE — The 5.6× Risk Multiplier
🦠
DYSBIOSIS
Gut imbalance detected
F/B > 2, Akk < 3%
→
🧱
GUT BARRIER
Week -6: Leaky gut
LPS leak starts
→
⚡
CYTOKINE STORM
Week -4: IL-6 surge
inflammation × 5.6
→
🔄
METABOLIC SHIFT
Week -2: IR onset
HOMA-IR ≥ 2.5
→
🫀
CLINICAL
Week 0: Diagnosis
Disease manifests
→
💸
CLAIMS COST
Without BURAK
1.2M+ AED
⚠️ DYSBIOSIS = ROOT CAUSE: Gut imbalance triggers cascade → 5.6× higher risk of T2DM, CVD, NAFLD, CKD
004 — PARTNER WITH US

For Payers & Payees

We're moving into production. We want to understand your workflow — and in return, offer you a free pilot program to see the results firsthand.

🏦

PAYERS

Insurance Companies • TPAs • Self-Insured Employers

What You Could Gain

  • ✓ Reduced Claims Costs — Early intervention prevents expensive acute events
  • ✓ Risk Stratification — Identify high-risk members before they become high-cost
  • ✓ Better Loss Ratios — Predict and prevent instead of react and pay
  • ✓ Competitive Advantage — Offer predictive wellness to your members

Potential ROI per 1,000 members:

Millions in Savings

(Exact figures to be validated in pilot)

🏥

PAYEES

Hospitals • Government Health • Clinics • Health Systems

What You Could Gain

  • ✓ Better Patient Outcomes — Catch disease before it becomes critical
  • ✓ Increased ROI Per Patient — Prevention costs less than treatment
  • ✓ Reduced Readmissions — Address root causes, not just symptoms
  • ✓ Population Health Insights — Understand your community's health trajectory

Goal per patient cohort:

8-Week Early Warning

(Based on peer-reviewed research)

🚀

Free Pilot Program

We're looking for partners to validate our approach. In exchange for helping us understand your workflow, we'll run a free pilot on a cohort of your patients — so you can see the results before any commitment.

Step 1
We learn your workflow
→
Step 2
Select patient cohort
→
Step 3
Run BURAK analysis
→
Step 4
Review results together
🔒

Patient Safety & Data Security

We take data privacy seriously. Our production pipelines are being deployed on Google Cloud Healthcare Containers — built for HIPAA compliance and healthcare-grade security.

🔐 Anonymized Data Only
We work with patterns, not identities
☁️ Google Cloud Healthcare
Enterprise-grade infrastructure
📋 Clinical Team Access
Your team can deep-dive on reports
START A CONVERSATION →

Connect with Waseem Ahmad Ahanger on LinkedIn

No commitment required. Let's explore together.

005 — THE TEAM

Who We Are

A group of engineers and scientists building tools to apply breakthrough research in clinical practice.

🧬
AI in Oncology
Experience deploying ML in clinical settings
📊
Predictive Systems
Built prediction engines at scale (AWS)
🔬
Lab Integration
Automated lab workflows with AI
💻
Core Engineering
Software & mathematical sciences

Our mission: Take peer-reviewed scientific research and build practical tools that clinicians and health systems can actually use.

006 — THE SCIENCE

Research Foundation

BURAK is built on peer-reviewed gut-metabolic axis research. Here's how we're applying these scientific findings.

📄 What The Published Research Shows

🦠 Gut-Metabolic Connection

Studies show dysbiosis (gut imbalance) precedes metabolic disease by weeks to months. Changes in F/B ratio and Akkermansia levels correlate strongly with future T2DM, CVD, and NAFLD.

Source: Peer-reviewed studies, healthcare scientific committee approved

🔥 Inflammation Amplifier

Research demonstrates that inflammatory markers (CRP, IL-6) amplify the gut-blood connection. Patients with elevated inflammation show 5-6× higher progression rates to clinical disease.

Source: Meta-analyses of gut-inflammation-metabolism pathway

⚡ The Velocity Hypothesis

The key insight from the research: gut markers change slowly (weeks/months) while blood markers change quickly (days/weeks). When blood markers spike but gut markers remain stable, it indicates acute metabolic stress — a predictive window before clinical disease manifests.

🔧 How BURAK Applies This Research

📥

1. Collect Data

We gather the biomarkers identified in the research: gut microbiome, blood metabolics, inflammation

⚡

2. Calculate Velocity

We measure the rate of change in each layer and calculate the velocity delta as described in research

🎯

3. Flag Risk

When velocity delta exceeds research-defined thresholds, we flag for early intervention

📊 Example: Applying The Research Formula

Here's how the velocity calculation would work based on the research parameters:

Vgut
0.12
Slow baseline
Vblood
2.34
Fast signal
Ainfl
5.6
Amplifier
Δ
12.43
Above threshold (8.0)
Formula from research: |Vblood − Vgut| × Ainflammation = |2.34 − 0.12| × 5.6 = 12.43

What This Means: If the research is correct, a velocity delta of 12.43 (above the 8.0 threshold) would indicate elevated risk approximately 8 weeks before clinical symptoms appear.

📊 Research-Based Cohort → Disease Relationships

Based on published studies, these biomarker patterns show strong correlations with disease outcomes. BURAK tracks these relationships to identify at-risk individuals.

HIGH F/B Gut Imbalance LOW Akk Barrier Loss HIGH CRP Inflammation HIGH HOMA Insulin Resist. T2DM Type 2 Diabetes CVD Cardiovascular NAFLD Fatty Liver CKD Kidney Disease Research shows 5-6× higher risk EARLY WARNING ~8 weeks
Relationships based on published peer-reviewed research on gut-metabolic axis

BURAK applies findings from 3+ years of peer-reviewed gut-metabolic research approved by healthcare scientific committees. We're building tools to make this research actionable in clinical practice.